At the Bench

Over the last few decades, scientists have discovered that long-term calorie restriction provides a wealth of benefits in animals: lower weight, better blood sugar control, even longer lifespans. Researchers have largely assumed that reduced food intake drove these benefits by reprogramming metabolism. But a new study led by Dudley Lamming...
1. Aggarwal R, Rydzewski NR, Zhang L, Foye A, Kim W, Helzer KT, Bakhtiar H, Chang SL, Perry MD, Gleave M, Reiter RE, Huang J, Evans CP, Alumkal JJ, Lang JM, Yu M, Quigley DA, Sjöström M, Small EJ, Feng FY, Zhao SG. Prognosis Associated With Luminal and Basal Subtypes...
In critical care, the first step in improving patient outcomes is identifying what drives mortality. Often these drivers are a complex mix of individual patient factors and systems factors, both of which may vary across hospitals, regions and countries. Since the beginning of the COVID-19 pandemic, emerging data has shown...
Akel MA, Carey KA, Winslow CJ, Churpek MM, Edelson DP. Less is More: Detecting Clinical Deterioration in the Hospital with Machine Learning Using Only Age, Heart Rate, and Respiratory Rate. Resuscitation. 2021. Beathard GA, Jennings WC, Wasse H, Shenoy S, Falk A, Urbanes A, Ross J, Nassar G, Hentschel DM...
A pair of studies recently published in the New England Journal of Medicine report that therapeutic-dose anticoagulation with heparin appears to improve outcomes for non-critically ill patients hospitalized with COVID-19, but not for critically ill patients hospitalized with the disease. The studies are the result of an international, multiplatform, randomized...
1. Adams MT, Dwulet JM, Briggs JK, Reissaus CA, Jin E, Szulczewski JM, Lyman MR, Sdao SM, Kravets V, Nimkulrat SD, Ponik SM, Merrins MJ, Mirmira RG, Linnemann AK, Benninger RK, Blum B. Reduced synchroneity of intra-islet Ca(2+) oscillations in vivo in Robo-deficient β cells. Elife. 2021;10. 2. Alagoz O...
Over 40% of physicians, nationwide, experience burnout, a condition characterized as a long-term stress reaction due to regulatory pressures, time constraints and evolving care-delivery models that can cause a decrease in care quality, high physician turnover, and mental health problems. While burnout is a complex issue that will require various...
1. Abler LL, O'Driscoll CA, Colopy SA, Keil Stietz KP, Wang P, Wang Z, Hartmann F, Crader-Smith SM, Ouellette JN, Mehta V, Oakes S, Grimes MD, Mitchell GS, Baan M, Gallagher SJ, Davis DB, Kimple ME, Bjorling DE, Watters JJ, Vezina CM. The influence of intermittent hypoxia, obesity and diabetes...
Marina Sharifi, MD, PhD, fellow, Hematology, Medical Oncology and Palliative Care, is one of 11 subspecialty fellows in the U.S. to receive a grant from the Doris Duke Physician Scientist Fellowship, a program of the Doris Duke Charitable Foundation (DDCF). The grant will support Dr. Sharifi’s research project, “Multiplex Liquid...
In 2014, Dudley Lamming, PhD, associate professor, Endocrinology, Diabetes and Metabolism, was reading a study out of Australia that looked at how mice responded to dozens of controlled diets when one thing caught his attention: The mice fed the least amount of protein were the healthiest. “That was really interesting...