At the Bench

New research from Dudley Lamming, PhD, associate professor, Endocrinology, Diabetes and Metabolism, is one step closer to understanding the metabolism-regulating complex mTORC2, and the role it may have in regulating lifespan. The protein complex mTORC2 influences lifespan in yeast, worms, flies, and mice. In a 2014 study by Dr. Lamming...
A recent case report from Lindsay Taylor, MD, fellow, Infectious Disease, and E. Ann Misch, MD, assistant professor, Infectious Disease, discusses how a kidney transplant patient acquired Powassan virus through blood transfusion. The patient, from Indiana, presented with headache, fever, weakness, myalgias, diarrhea and progressive encephalitis 24 days after renal...
1. Arriola Apelo SI, Lin A, Brinkman JA, Meyer E, Morrison M, Tomasiewicz JL, Pumper CP, Baar EL, Richardson NE, Alotaibi M, Lamming DW. Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging. Elife. 2020;9. 2. Aziz F, Jorgenson MR, Garg N, Mohamed...
The University of Wisconsin Institute for Clinical and Translational Research (UW ICTR) recently announced the recipients of the 2020 Pilot Grant Awards. The following Department of Medicine faculty and staff members received funding. Translational Basic & Clinical Pilot Awards (up to $50,000 for 12 months of direct support) Jianhua Zhang...
A new prevention research study at the University of Wisconsin School of Medicine and Public Health is looking at whether a commonly used oral and nasal antiseptic (in addition to personal protective equipment and hand hygiene) can help prevent COVID-19 infections in frontline healthcare workers. Povidone iodine and chlorhexidine gluconate...
Angulo E, Joyner S, Majeed NK, Nyenhuis S. A rare case of peliosis hepatis in primary immune deficiency. In: SAGE Open Med Case Rep. Vol 8. © The Author(s) 2020.; 2020:2050313x20931996. Aziz F, Muth B, Parajuli S, Garg N, Mohamed M, Mandelbrot D, Djamali A. Unusually high rates of acute...
Research by Amy Kind, MD, PhD, associate professor, Geriatrics and Gerontology, that shares measures of socioeconomic disadvantage at the neighborhood level is now influencing policy on fair allocation of medications to treat patients with COVID-19. The Neighborhood Atlas, developed by Dr. Kind’s team and launched in 2018, shares metrics from...
Study objectives: The authors aimed to estimate the false-negative rate of the SARS-CoV-2 RT-PCR by days since infection. Methods and Results: Data from seven previously published studies on reverse transcriptase polymerase chain reaction (RT-PCR) performance by time since symptom onset were included in a pooled analysis. The studies included a...
Abou-Alfa GK, Macarulla T, Javle MM, Kelley RK, Lubner SJ, Adeva J, Cleary JM, Catenacci DV, Borad MJ, Bridgewater J, Harris WP, Murphy AG, Oh DY, Whisenant J, Lowery MA, Goyal L, Shroff RT, El-Khoueiry AB, Fan B, Wu B, Chamberlain CX, Jiang L, Gliser C, Pandya SS, Valle JW...
Study objectives: Research letter to determine if the Bacillus Calmette–Guérin (BCG) vaccine administered in childhood for tuberculosis reduces the rate of COVID-19 infections. Methods and Results: The BCG vaccine was routinely administered to all newborns in Israel between 1955 and 1982 with high acceptability and coverage amongst citizens. Since 1982...