COVID-19

A new prevention research study at the University of Wisconsin School of Medicine and Public Health is looking at whether a commonly used oral and nasal antiseptic (in addition to personal protective equipment and hand hygiene) can help prevent COVID-19 infections in frontline healthcare workers. Povidone iodine and chlorhexidine gluconate...
Research by Amy Kind, MD, PhD, associate professor, Geriatrics and Gerontology, that shares measures of socioeconomic disadvantage at the neighborhood level is now influencing policy on fair allocation of medications to treat patients with COVID-19. The Neighborhood Atlas, developed by Dr. Kind’s team and launched in 2018, shares metrics from...
Study objectives: The authors aimed to estimate the false-negative rate of the SARS-CoV-2 RT-PCR by days since infection. Methods and Results: Data from seven previously published studies on reverse transcriptase polymerase chain reaction (RT-PCR) performance by time since symptom onset were included in a pooled analysis. The studies included a...
Christopher Crnich, MD, PhD, associate professor, Infectious Disease (pictured at right), and collaborators have received a UW Institute for Clinical and Translational Research (ICTR) 2020 COVID-19 Response Grant Award. This award was one of three new awards extending the 22 awards previously announced by the Wisconsin Partnership Program to address...
When Mariah Quinn, MD, MPH, assistant professor (CHS), General Internal Medicine, assumed the role of Director of Medicine Provider Well-being in 2019, burnout, engagement and work-life-balance were issues being examined at systems and work-environment levels. More recently, as the COVID-19 pandemic disrupted healthcare services and the ways in which we...
Study objectives: Research letter to determine if the Bacillus Calmette–Guérin (BCG) vaccine administered in childhood for tuberculosis reduces the rate of COVID-19 infections. Methods and Results: The BCG vaccine was routinely administered to all newborns in Israel between 1955 and 1982 with high acceptability and coverage amongst citizens. Since 1982...
Background: Protocolized prone positioning has been shown to decrease mortality in patients with severe ARDS requiring mechanical ventilation [2]. Patients with COVID-19 can develop severe hypoxemic respiratory failure, with recent physiologic and autopsy studies showing similar pathophysiology to ARDS [3,4]. Methods: Single-center prospective before-after study of prone positioning in nonintubated...
Purpose: A study to investigate the relationship between underlying cardiovascular disease and COVID-19 outcomes in addition to evaluating the association between cardiovascular drug therapy and mortality in patients with COVID-19. Study Design: Observational study using de-identified data from the Surgical Outcomes Collaborative international registry from 169 hospitals in Asia, Europe...
Alan Bridges, MD, professor (CHS), Rheumatology, senior vice chair, Department of Medicine, and chief of staff at the William S. Middleton Memorial Veterans Hospital, is an expert advisor on post–COVID-19 operations at the Veterans Health Administration (VHA)—at both the national and regional levels. In late April, Dr. Bridges was invited...
Background: Remdesivir is a nucleoside analogue prodrug that has been shown to inhibit human and animal coronaviruses in animal models, and SARS-CoV-2 in vitro. Methods: Randomized, double-blind, placebo-controlled trial in 10 hospitals in Hubei, China [1]. Patients with lab confirmed COVID-19 pneumonia with 12 days or fewer of symptoms were...