Research - Recent Publications

Scientists at the University of Wisconsin–Madison, including David Andes, MD, professor, Infectious Disease, have discovered a new antifungal compound found in the microbiome of a sea squirt from the Florida Keys. The antifungal, which the scientists named turbinmicin, efficiently targets multi-drug–resistant strains of deadly fungi without toxic side effects in...
Matthew Merrins, PhD, assistant professor, Endocrinology, Diabetes and Metabolism, recently led a study on insulin secretion that has changed previous thinking, and could open up doors for new research to be done on diabetes treatments. Dr. Merrins and his colleagues look at activating the enzyme, pyruvate kinase, as a way...
1. Abulizi A, Cardone RL, Stark R, Lewandowski SL, Zhao X, Hillion J, Ma L, Sehgal R, Alves TC, Thomas C, Kung C, Wang B, Siebel S, Andrews ZB, Mason GF, Rinehart J, Merrins MJ, Kibbey RG. Multi-Tissue Acceleration of the Mitochondrial Phosphoenolpyruvate Cycle Improves Whole-Body Metabolic Health. Cell Metab...
Shivani Garg, MD, MS, assistant professor, Rheumatology, was the lead author on a study that found Black patients with lupus in the U.S. have a three times higher risk of stroke and a 24-fold higher risk for ischemic heart disease. The researchers also identified risk factors that were predictive of...
By tracking COVID-19 virus mutation, a study published in Nature Communications that includes co-authors Nasia Safdar, MD, PhD, and Caitlin Pepperell, MD, FRCPC, shows the success that stay-at-home orders had in preventing the spread of the virus. According to an analysis of the genome sequences of virus samples collected from...
As the COVID-19 pandemic took hold in regions across the United States in the spring, governors, mayors and local leaders hoping to quell the spread of the virus turned to the only actionable defenses available at the time: They closed schools and businesses, banned mass gatherings, issued stay-at-home orders and...
1. Al-Adra DP, Hammel L, Roberts J, Woodle ES, Levine D, Mandelbrot D, Verna E, Locke J, D'Cunha J, Farr M, Sawinski D, Agarwal PK, Plichta J, Pruthi S, Farr D, Carvajal R, Walker J, Zwald F, Habermann T, Gertz M, Bierman P, Dizon DS, Langstraat C, Al-Qaoud T, Eggener...
While most people associate improvisation, or improv, with comedic acting, Amy Zelenski, PhD, assistant professor, General Internal Medicine, also associates improv with a way to teach health professionals how to relate to one another. The results from her work with medical students and health professionals on the effectiveness of improv...
1. Anandan A, Sharifi M, O'Regan R. Molecular Assays to Determine Optimal Duration of Adjuvant Endocrine Therapy in Breast Cancer. Curr Treat Options Oncol. 2020;21(10):84. 2. Aziz F, Mandelbrot D, Singh T, Parajuli S, Garg N, Mohamed M, Astor BC, Djamali A. Early Report on Published Outcomes in Kidney Transplant...
New research from Dudley Lamming, PhD, associate professor, Endocrinology, Diabetes and Metabolism, is one step closer to understanding the metabolism-regulating complex mTORC2, and the role it may have in regulating lifespan. The protein complex mTORC2 influences lifespan in yeast, worms, flies, and mice. In a 2014 study by Dr. Lamming...